Abnormal growth and embryonic lethality of <i>Lemd2</i>^Gt/Gt mice.

<p>(<b>A</b>) Genotypes of embryos and pups produced from intercrossing of <i>Lemd2</i>^<i>+/Gt</i> animals. (<b>B, C</b>) Bright-field images of <i>Lemd2</i>^<i>+/+</i> (left) and <i>Lemd2</i>^<i>Gt/Gt</i> (right) embryos at E10.5. (<b>B</b>) Views of embryos within yolk sacs. (<b>C</b>) Views of embryos with yolk sacs removed. (<b>D</b>) Crown-to-rump length of embryos at E9.5 and E10.5. <i>Lemd2</i>^<i>+/+</i><i>n</i> = 6; <i>Lemd2</i>^<i>Gt/Gt</i><i>n</i> = 5. Data are presented as mean ± SD. (*<i>p</i> < 0.0005, **<i>p</i> < 0.005). (<b>E</b>) Sagittal sections of <i>Lemd2</i>^<i>+/+</i> and <i>Lemd2</i>^<i>Gt/Gt</i> E10.5 embryos stained with H&E. Bars: 500 μm.