<p>Genes that encode more than one cancer-type-specific significantly mutated domain instance.</p
<p>Rectangles represent protein domain instances in a given gene. Colored dots represent mutations d...
<p>(<b>A</b>) The 96 metabolic genes that are recurrently mutated in samples (≥ 5%). The functional ...
One of the biggest mysteries in cancer research remains why mutations in certain genes cause cancer ...
<p>Significantly mutated domain instances and corresponding genes in each cancer type.</p
<p>Prevalence of predicted damaging mutations in domain instances among cancer types.</p
<p>The heatmap reflects the significance of cancer-type-specific mutation density of each domain ins...
Genes having mutations, which were assessed as a high or moderate impact and confirmed in the COSMIC...
Abstract Background Discriminating driver mutations from the ones that play no role in cancer is a s...
<p>(A) compares the prevalence with which mutations from a specific cancer type fall within signific...
<p>A. shows the distribution of mutational hotspots for different cancer types within a given domain...
<p>Domain position-based mutational hotspots shared by at least three cancers with functional annota...
The accumulation of multiple genetic changes underlies the process of tumorigenesis, and both domina...
Identifying driver mutations and their functional consequences is critical to our understanding of c...
Protein domains are conserved structural and functional units of proteins. We have used OncoMD data ...
<div><p>Identifying driver mutations and their functional consequences is critical to our understand...
<p>Rectangles represent protein domain instances in a given gene. Colored dots represent mutations d...
<p>(<b>A</b>) The 96 metabolic genes that are recurrently mutated in samples (≥ 5%). The functional ...
One of the biggest mysteries in cancer research remains why mutations in certain genes cause cancer ...
<p>Significantly mutated domain instances and corresponding genes in each cancer type.</p
<p>Prevalence of predicted damaging mutations in domain instances among cancer types.</p
<p>The heatmap reflects the significance of cancer-type-specific mutation density of each domain ins...
Genes having mutations, which were assessed as a high or moderate impact and confirmed in the COSMIC...
Abstract Background Discriminating driver mutations from the ones that play no role in cancer is a s...
<p>(A) compares the prevalence with which mutations from a specific cancer type fall within signific...
<p>A. shows the distribution of mutational hotspots for different cancer types within a given domain...
<p>Domain position-based mutational hotspots shared by at least three cancers with functional annota...
The accumulation of multiple genetic changes underlies the process of tumorigenesis, and both domina...
Identifying driver mutations and their functional consequences is critical to our understanding of c...
Protein domains are conserved structural and functional units of proteins. We have used OncoMD data ...
<div><p>Identifying driver mutations and their functional consequences is critical to our understand...
<p>Rectangles represent protein domain instances in a given gene. Colored dots represent mutations d...
<p>(<b>A</b>) The 96 metabolic genes that are recurrently mutated in samples (≥ 5%). The functional ...
One of the biggest mysteries in cancer research remains why mutations in certain genes cause cancer ...
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