Investigation of the renal stroma in <i>β-cat</i>^<i>S-/</i>- mutant kidneys.

<p>(A-L) Analysis of the renal stroma using stromal markers; Meis1/2, Pbx1, Foxd1, and TN-C at E15.5. As compared to <i>WT</i>, no overt changes were observed in the cortical stroma with respect to Meis1/2 (A, B), Pbx1 (E, F), Foxd1 (I, J), and TN-C (K, L). However, a reduction of Meis1/2 (C, D) and Pbx1 (G, H) was observed in the medullary region in <i>β-cat</i>^<i>S-/</i>- kidneys. (M, N) TUNEL assay at E15.5 reveals an increase in apoptosis in the medullary stroma of <i>β-cat</i>^<i>S-/</i>- kidneys compared to <i>WT</i>. (rc = renal capsule, cs = cortical stroma, ms = medullary stroma, A = apoptosis). Scale Bar = 50μm