Model selection.

<p>A) Rankings represent the forward selection approach using selected minimal model structures; B) backward selection where the building blocks are removed from the complete model; C) the model combination selection. D) Comparison of the predictive power of the complete model and 4_8_12 model in respect of the kinetic of “active PI3K”. Confidence intervals of the predictions are indicated by shaded areas. E) Ranking of model selection including minimal model structures, model combinations and random models is shown. All rankings of model selection present the negative logarithmic likelihood penalized by parameter difference as described in Materials and Methods on the y-axis. Model identifiers are shown on the x-axis.