Localisation of CHOP in the SON and PVN.

<p>(A-B) Immunostaining of CHOP (green) and AVP (red) in the (A) SON and (B) PVN of 3 days DH and 7 days SL rats shows expression of CHOP in the nuclei of AVP MCNs. (C-D) Immunostaining of CHOP (red) and CREB3L1 (green) in the (C) SON and (D) PVN of 3 days DH and 7 days SL rats shows co-existence of CHOP and CREB3L1 in the same MCNs. High magnification confocal microscope images shows a change in localisation of CREB3L1 from perinuclear staining in control to cytoplasmic and nuclear staining in both 3 days DH and 7 days SL. Arrows indicate perinuclear staining of CREB3L1. d, day; DH, dehydration; SL, salt loading; AVP, arginine vasopressin.