Effect of 7-day treatment with different doses of Cipro derivatives on the survival mice.

<p>Swiss Webster mice were infected i.p. with 5x10³ tachyzoites of <i>T</i>. <i>gondii</i> (RH strain) one day prior to the start of treatment. Results were evaluated by the Kaplan-Meier product limit method, and compared using the log-rank (Mantel-Cox) test. * <i>P</i><0.05 vs. untreated controls. The numbers of treated mice in each group were: untreated, 10 (A), 14 (B and D) and 15 (C); 50 and 100 mg Cipro, 11 (three groups each); 150 mg Cipro, 8 (two groups); 50 and 100 mg Et-Cipro, 11 (three groups); 50 and 100 mg Ph-Cipro, 8 (two groups); 150 mg Ph-Cipro, 11 (three groups); 50 mg Adam-Cipro, 3 (one group); 100 mg Adam-Cipro, 12 (three groups).