CXCR4 antagonist treatment protects DBA/2 mice from ALI/ARDS.

<p>(A) Survival and (B) parasitemia curves in <i>P</i>. <i>berghei</i> ANKA-infected mice treated with 5 mg/kg of AMD3100 or DMSO + saline solution (control group) on the 1^st, 3^rd, 5^th and 7^th days post-infection (dpi). (C) Lung tissues from untreated mice (CTR) (died on the 9^th dpi with ALI/ARDS) and AMD3100-treated mice (died on the 21^st dpi due to hyperparasitemia) (400x, scale bar 25 μm). (D) Number of neutrophils in the lungs, measured via flow cytometry, from infected AMD3100-treated mice and control mice (CTR). (E) Enhanced respiratory pause (Penh) and (F) respiratory frequency (RF) data for these mice. Data are representative of three independent experiments and are expressed as the mean ± SEM. The data from (D) to (F) were collected on the 7^th dpi. (A, log-rank test and Wilcoxon-Gehan-Breslow test, p<0.05; Mann Whitey-test, *p<0.05, ** p<0.01 and *** p<0.001; n = 10–15 mice/experiment). The dashed line represents the mean value for the non-infected mice (NI).