c-Met is a critical downstream target of miR-144 (A) Targetscan analysis using available algorithms indicated that c-Met is a theoretical target gene of miR-144.

<p>(B) Luciferase reporter gene assays showed that ectopic of miR-144 remarkably reduced luciferase activity in the c-Met wild-type reporter gene but not the mutant c-Met 3’UTR.(C) qRT-PCR analysis of c-Met expression in the MUM-2B cells which was transected miR-144 mimics, inhibitors, scramble or control. GAPDH was used as internal control. (D) Western blot analysis has shown that miR-144 mimic inhibited the protein expression of c-Met in MUM-2B cells. GAPDH was also detected as a loading control. ***p<0.001.