MDM2 lid structural ensembles and contact details from representative structures for the five systems studied.
- Juan A. Bueren-Calabuig (749993)
- Julien Michel (151377)
Publication date
June 2015
DOIAbstract
<p>A) Apo-MDM2. Structural ensemble (A1) and structural details of the closed (A2) and open states (A3). B) p53-MDM2 complex. Structural ensemble (B1) and structural details (B2). C) Nutlin3a-MDM2 complex. Structural ensemble (C1) and structural details (C2). D) Bzd-MDM2 complex. Structural ensemble (D1) and structural details (D2). E). Pip2-MDM2 complex. Structural ensemble (E1) and structural details (E2). The X-ray structure of Pip2-MDM2 from Michelsen et al. is shown in red cartoon.[<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004282#pcbi.1004282.ref024" target="_blank">24</a>] Representatives PDB files are included in the Supporting Information.</p
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