Summary of Drug Titrations Showing 50% Inhibitory Concentration, IC₅₀, for the P-gp^± Cell Lines Treated with Paclitaxel and Derivatives (and ± Verapamil).

<p>The IC₅₀ values are given in nM. Values and errors (SE) shown are representative of n = 3 independent experiments.</p><p>* P < 0.05 determined for IC₅₀ for an analog relative to paclitaxel.</p><p>^‡ P < 0.05 determined for IC₅₀ for an analog with improved potency relative paclitaxel.</p><p>^§ VRP is verapamil.</p><p>^¶ P-gp⁺ cell line.</p><p>Summary of Drug Titrations Showing 50% Inhibitory Concentration, IC₅₀, for the P-gp^± Cell Lines Treated with Paclitaxel and Derivatives (and ± Verapamil).