<p>(A-C) MDA-MB-453 cells were treated with the indicated concentration of anti-cancer drugs paclitaxel, 5-fluorouracil and cyclophosphamide respectively and the cell survival was determined using MTT assay. (D) Table showing the IC<sub>50</sub> concentration of drugs determined using the survival curves. Error bars are means ± SD of three independent experiments; (*p < 0.05, **p < 0.01, ***p < 0.001).</p
<p>(<b>A</b>) Tumor growth curve. Data are presented as tumor volumes in each group (n = 6 tumors/gr...
<p>Cells were pre-treated with 50 µM pan-caspase inhibitor Z-VAD-FMK prior to treatment with 3.2 µM ...
<p>The cytotoxicities of compounds <b>3a</b>–<b>g</b> are expressed as percentage of cell growth rel...
<p>A. The structures of B02, doxorubicin, etoposide, topotecan and cisplatin. B. Survival of MDA-MB-...
<p>A, Apoptotic effect of anticancer drug cisplatin (5–20 μM) in response to antioxidant EGCG (50 μM...
<p>(A) Effect of DHT stimulation on cell survival caused by paclitaxel, 5-fluorouracil and cyclophos...
<p>A. MDA-MB-231 cells were exposed to cisplatin (in indicated concentrations) in the absence or pre...
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
<p>KPT-330 resistant 786-O (R1 and R2) and parental (P) cells were treated with KPT-330 at the indic...
<p>(<b>A</b>) TUNEL staining. Data are presented as mean number of TUNEL-positive cells in each imag...
<p>A-F) The line graph shows the cell viability (%) in MDA-MB-231 cells stably expressing NT or shAB...
<p>Error bars are presented as the SD (standard deviation) of three duplicate determinations.</p
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
These results suggest PBRM1 mutant cells may be more sensitive to both the PARP and ABL1 inhibitors ...
<p>a) Clonogenic assay performed in DU-145 after treatment with different doses of VPA for 48 h befo...
<p>(<b>A</b>) Tumor growth curve. Data are presented as tumor volumes in each group (n = 6 tumors/gr...
<p>Cells were pre-treated with 50 µM pan-caspase inhibitor Z-VAD-FMK prior to treatment with 3.2 µM ...
<p>The cytotoxicities of compounds <b>3a</b>–<b>g</b> are expressed as percentage of cell growth rel...
<p>A. The structures of B02, doxorubicin, etoposide, topotecan and cisplatin. B. Survival of MDA-MB-...
<p>A, Apoptotic effect of anticancer drug cisplatin (5–20 μM) in response to antioxidant EGCG (50 μM...
<p>(A) Effect of DHT stimulation on cell survival caused by paclitaxel, 5-fluorouracil and cyclophos...
<p>A. MDA-MB-231 cells were exposed to cisplatin (in indicated concentrations) in the absence or pre...
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
<p>KPT-330 resistant 786-O (R1 and R2) and parental (P) cells were treated with KPT-330 at the indic...
<p>(<b>A</b>) TUNEL staining. Data are presented as mean number of TUNEL-positive cells in each imag...
<p>A-F) The line graph shows the cell viability (%) in MDA-MB-231 cells stably expressing NT or shAB...
<p>Error bars are presented as the SD (standard deviation) of three duplicate determinations.</p
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
These results suggest PBRM1 mutant cells may be more sensitive to both the PARP and ABL1 inhibitors ...
<p>a) Clonogenic assay performed in DU-145 after treatment with different doses of VPA for 48 h befo...
<p>(<b>A</b>) Tumor growth curve. Data are presented as tumor volumes in each group (n = 6 tumors/gr...
<p>Cells were pre-treated with 50 µM pan-caspase inhibitor Z-VAD-FMK prior to treatment with 3.2 µM ...
<p>The cytotoxicities of compounds <b>3a</b>–<b>g</b> are expressed as percentage of cell growth rel...