Local microglia ablation in tumor area reduces phosphorylation of Pyk2 in implanted GL261 glioma tumors in CD11b-HSVTK transgenic mice.
- Kimberleve Rolón-Reyes (758481)
- Yuriy V. Kucheryavykh (758482)
- Luis A. Cubano (383851)
- Mikhail Inyushin (564682)
- Serguei N. Skatchkov (564685)
- Misty J. Eaton (564684)
- Jeffrey K. Harrison (160216)
- Lilia Y. Kucheryavykh (726101)
Publication date
June 2015
DOIAbstract
<p><b>(A)</b> Western blot detection of pPyk2 (Tyr 579/580) protein in glioma cells extracted from C57BL/6 and HSVTK-CD11b mice brains after treatment with GCV. Glioma cells were purified using Percoll gradients. <b>(B)</b> The graph shows the quantification of corresponding levels of pPyk2(Tyr 579/580) detected by western blot. Mean ± S.E and significant difference from control (*) is shown (p < 0.05).</p
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