Trypanosomosis drastically affects the titers of circulating anti-CII IgG Abs.

<p>DBA/1 mice were immunized primarily with CII in CFA on day 0 and secondarily with CII in IFA on day 21. One group of mice was infected with <i>T</i>. <i>brucei</i> (filled and open triangle) on day 14 i.p. and the other was left untreated (filled and open square). Serial serum dilution levels of anti-CII (<b>A</b>) IgG1, (<b>B</b>) IgG2a, (<b>C</b>) IgG2b and (<b>D</b>) IgM Abs were measured by ELISA on day 14 (before infection, filled square and triangle) and day 35 (open square and triangle). Graphs show the mean ± SD from at least n = 6 mice per group and the data are representative of two independent experiments.