Trypanosomosis substantially delays the onset of CIA in DBA/1 prone mice.

<p>DBA/1 mice were immunized primarily with CII in CFA on day 0 and secondarily with CII in IFA on day 21. One group of mice was infected with <i>T</i>. <i>brucei</i> (filled triangle) on day 14 i.p. and the other was left untreated (filled square). (<b>A</b>) Average clinical score and (<b>C</b>) the number of arthritic limb per mouse were followed starting at day 0. (<b>B</b>) Representative pictures of arthritic limbs at day 42. Graphs show the mean ± SD from at least n = 6 mice per group and the data are representative of three independent experiments. (D&E) DBA/1 mice were infected with <i>T</i>. <i>brucei</i> i.p. and (<b>D</b>) survival and (<b>E</b>) blood parasite counts were monitored. Graphs show the mean ± SD from at least n = 6 mice per group and the data are representative of two independent experiments.