Observed metabolite changes mapped onto the pathways involved in the pentose phosphate pathway.

<p>Changes in the metabolite levels in the skeletal muscle of PGC-1α-Tg mice and WT mice are shown. Relative metabolite changes shown in the graphs were obtained by CE-TOFMS (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129084#pone.0129084.s002" target="_blank">S1 Table</a>). Open bars, WT and filled bars, PGC-1α-Tg (N = 3). Data are expressed as the mean ± SD. Asterisks indicate statistically significant differences (**p < 0.01, *p < 0.05). Microarray data of gene expression change of enzymes in the related metabolic process are shown in the scheme.