<p>(A,B) Grip strength and Rotarod measurements analyses at 15-months of age, (C,D) H&E and (E,F) Oil Red O staining of quadriceps muscle from WT and VCP<sup><b>R155H/+</b></sup> animals placed on the 9%, 12%, 30%, and 48% LED from birth. The number of mice analyzed per experiment is 8–10. Insets show magnified pathology, including rimmed vacuoles (orange arrows), atrophy (blue arrows), centralized nuclei (green arrows), and increased lipid droplets (white arrows).</p
<p>(A–C) Quadricep muscles from 9–10 month-old wild-type and VCP<sup>R155H/+</sup> knock-in mice wer...
<p><b>(A-D)</b> Sirius red staining of gastrocnemius muscle from wild-type (120 days old) and sympto...
<p>(A) Fiber size (cross-sectional area, pixels) was measured in tibialis anterior (TA) and soleus m...
<p>(A) Grip strength measurements for the WT (blue) and VCP<sup><b>R155H/+</b></sup> (red) mice plac...
<p>(A) Weight measurements of WT and VCP<sup>R155H/+</sup> mice. (B) Muscle strength impairment obse...
<p>(A) Lateral view of hindlimbs from WT and NF90 Tg mice (line TG1) at 12 weeks of age. An arrow in...
<p>Red bars represent 15 weeks on diet, green 30 weeks. C57Bl/6 and ApoE -/- mice are denoted as “+/...
<p><i>A</i>) Average grip strength of αB-R120G heterozygous (n = 27), homozygous (n = 20), or wild-t...
<p>(A) VCP<sup>R155H/R155H</sup> mice are much smaller and weaker and demonstrate gross abnormalitie...
<p>Quadriceps muscles from <b>(A,D)</b> vehicle control <b>(B,E)</b> rapamycin-treated or <b>(C,F)</...
<p>A: body weight of male (empty diamonds) and female (empty triangles) wild-type mice, and male (fi...
<p>TUNEL staining of quadriceps muscles from sedentary (A) WT and (B) VCP<sup>R155H/+</sup>; exercis...
<p>(<i>A</i>) Gastrocnemius and extensor digitorum longus muscle mass expressed as % of body mass fr...
<p>A, Mice fed a chow diet (Ch) or a high fat diet (F) were i.p. injected with PBS or 5-HT (1 mg/mou...
<p>(A) Oil Red O staining of WT and VCP<sup>R155H/R155H</sup> mice quadriceps reveals increased lipi...
<p>(A–C) Quadricep muscles from 9–10 month-old wild-type and VCP<sup>R155H/+</sup> knock-in mice wer...
<p><b>(A-D)</b> Sirius red staining of gastrocnemius muscle from wild-type (120 days old) and sympto...
<p>(A) Fiber size (cross-sectional area, pixels) was measured in tibialis anterior (TA) and soleus m...
<p>(A) Grip strength measurements for the WT (blue) and VCP<sup><b>R155H/+</b></sup> (red) mice plac...
<p>(A) Weight measurements of WT and VCP<sup>R155H/+</sup> mice. (B) Muscle strength impairment obse...
<p>(A) Lateral view of hindlimbs from WT and NF90 Tg mice (line TG1) at 12 weeks of age. An arrow in...
<p>Red bars represent 15 weeks on diet, green 30 weeks. C57Bl/6 and ApoE -/- mice are denoted as “+/...
<p><i>A</i>) Average grip strength of αB-R120G heterozygous (n = 27), homozygous (n = 20), or wild-t...
<p>(A) VCP<sup>R155H/R155H</sup> mice are much smaller and weaker and demonstrate gross abnormalitie...
<p>Quadriceps muscles from <b>(A,D)</b> vehicle control <b>(B,E)</b> rapamycin-treated or <b>(C,F)</...
<p>A: body weight of male (empty diamonds) and female (empty triangles) wild-type mice, and male (fi...
<p>TUNEL staining of quadriceps muscles from sedentary (A) WT and (B) VCP<sup>R155H/+</sup>; exercis...
<p>(<i>A</i>) Gastrocnemius and extensor digitorum longus muscle mass expressed as % of body mass fr...
<p>A, Mice fed a chow diet (Ch) or a high fat diet (F) were i.p. injected with PBS or 5-HT (1 mg/mou...
<p>(A) Oil Red O staining of WT and VCP<sup>R155H/R155H</sup> mice quadriceps reveals increased lipi...
<p>(A–C) Quadricep muscles from 9–10 month-old wild-type and VCP<sup>R155H/+</sup> knock-in mice wer...
<p><b>(A-D)</b> Sirius red staining of gastrocnemius muscle from wild-type (120 days old) and sympto...
<p>(A) Fiber size (cross-sectional area, pixels) was measured in tibialis anterior (TA) and soleus m...