Pairwise correlations of cluster distributions (using 10 clusters) of unfolding pathways of wild type <i>Bs</i>LipA and mutants from Rao <i>et al</i>.

<p>The upper triangle shows pairwise correlation coefficients as dial plots where a filled portion of a pie indicates the magnitude of the correlation (<i>r</i>) and blue (red) color indicates a positive (negative) correlation. The lower triangle shows 68% data ellipses (depicting the bivariate mean ± 1 standard deviation) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130289#pone.0130289.ref090" target="_blank">90</a>] and scatterplots of the respective cluster distributions (frequencies of network topologies in each of the 10 clusters) of the two <i>Bs</i>LipA variants as red lines smoothed by locally-weighted polynomial regression [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130289#pone.0130289.ref091" target="_blank">91</a>]. Data points and axes for the plots in the lower triangle are omitted for clarity. The blow-up in the right bottom corner depicts exemplarily for the TM <i>versus</i> WT case axes, axes labels, data points, the smoothing line obtained by locally-weighted polynomial regression, and the 68% data ellipsis. The figure was generated using the “corrgram” package [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130289#pone.0130289.ref092" target="_blank">92</a>] of the R program (<a href="http://www.r-project.org/" target="_blank">http://www.r-project.org</a>).