Rapamycin exaggerated FC-induced striatal injury in female mice.

<p><b>(A) Rapamycin (Rap) enhanced the LC3 immunoreactivity in DRD2 neurons of both male and female striatum.</b> The pictures were captured under fluorescent microscope after immunostaining. Arrows indicated the merged nuclei surrounded by LC3 and DRD2 immunoreactivity depicted DRD2 neurons with autophagic features. <b>(B) Rapamycin exaggerated FC-induced behavioral deficits in the female group. (C) Rapamycin increased the histological lesion ratio caused by FC infusion in the females.</b> The data are expressed as the means ± SDs (n = 6). **p<0.01 compared with sex-matched saline-infusion control. ##p<0.01 compared with the FC-infusion males. §p<0.05, §§p<0.01 compared with the FC-infusion females.