Epidemiological effect size of causative mutations at a single locus under two different penetrance models.

<p>The distribution of the log₁₀ odds ratio (log₁₀OR) is depicted for prevalence 0.1%-1.0% (A,D), 1%-5% (B,E) or 10%-20% (C,F), adopting either a multiplicative (A,B,C) or a logistic penetrance model (D,E,F). Blue: multiplicative model parameter γ = 0.3, logistic model parameters <i>α</i> = -5; <i>β</i> = 1; Red:γ = 0.1, <i>α</i> = -5; <i>β</i> = 0.5.