Different treatment strategies in a high hallmark mutation scenario.

<p>The graphs show the evolution through time iterations of the number Differentiated Cancer Cells—DCCs (continuous red line) with m = 1000 while the rest of the parameters were set to their standard values. Same setup as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132306#pone.0132306.g004" target="_blank">Fig 4</a>: a number of CSCs corresponding to 5% of the grid size is introduced from the beginning. A treatment is applied from the beginning only if the number of DCCs is equal or over a threshold value (1% of the grid size). a) A treatment is applied continuously, killing 5% of DCCs. b) The treatment is applied every 100 time iterations, continuously killing 10% of DCCs during 60 iterations. c) The treatment is applied every 100 time iterations, killing 50% of DCCs. d) The treatment is applied every 100 time iterations, killing 75% of DCCs.