The effect of different cancer stem cell treatment strategies on the time until disease progression.

<p>The figure shows the time until the disease burden increases despite continuous therapy versus the birth rate (panels <b>a</b> and <b>b</b>) and death rate (panels <b>c</b> and <b>d</b>) of cancer stem cells during therapy. The pre-treatment growth parameters are identical to those in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014366#pone-0014366-g002" target="_blank">Figure 2</a>, and also and , lastly we set . In panel <b>a,</b> we set for <i>i</i> = 0,1,2, and <i>u</i> = 5×10⁻⁹. The parameter varies along the x-axis and we consider three different values of <i>γ</i>. In panel <b>b</b>, we set for <i>i</i> = 0,1,2, and <i>γ</i> = 10⁻⁴. The parameter varies along the x-axis and we consider three different values of <i>u</i>. In panel <b>c</b>, we set for <i>i</i> = 1,2, <i>u</i> = 10⁻⁷, , vary along the x-axis and consider three different values of <i>γ</i>. In panel <b>d</b>, we set for <i>i</i> = 1,2, <i>γ</i> = 10⁻⁴, , vary along the x-axis and consider three different values of <i>u</i>.