Consensus sequences for mammalian progranulin.

<p>The mammalian polypeptide sequences were aligned at five levels of identity form 100% to 50%. Cysteine residues are highlighted in yellow. Amino acids are in capital letters on a background colour. Other letters and symbols are the default Mview notation for residue categories, (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133749#sec002" target="_blank">methods</a> for details). The colour scheme was adjusted to facilitate coordination with colours used in 3D models. The signal peptide is underlined. J indicates a joining sequence between modules, the granulin modules are identified by number and letter designations and the positions of exon boundaries are indicated by arrowheads. Paragranulin is a half granulin module at the N-terminus of mammalian progranulin.