The distribution of intramolecular coevolution amino acid residues mapped onto the human preproinsulin molecule 3D structure.

<p>The ribbons with different colors represent the four parts constituting the preproinsulin molecule, appearing as the signal peptide (green), B-chain (gray), C-peptide (skyblue), A-chain (cyan) in order. The amino acids involved in the coevolutionary analysis are displayed in spheres.