Protein disorder linked to habitat more than to phylogeny.

<p>The fractions of proteins with long disordered regions are predicted by two disorder predictor methods (MD in green bars and IUPred in red bars). Eukaryotes are predicted with substantially more disorder than prokaryotes. Within the kingdoms predictions vary greatly: organisms in similar habitats tend to resemble each other in terms of disorder more than they resemble their closest phylogenetic relatives. (A) Hyperthermophilic archaea (dark red) are more ordered than their phylogenetic neighbors; halophilic archaea are more disordered (green). (B) Halophilic bacteria also appear more disordered than their relatives. (C) The bacterial thermophile (red) also has less disorder than its relatives. Other extreme organisms included: psychrophile (blue), psychrotolerant (light blue), radiation resistant (purple) and alkalophile (pink). We could also find organisms with relative high/low disorder content explainable separately.