TEM images of Aβ40, Aβ42, and Aβ43 from 20% TFE in PB.

<p>Aβ40, Aβ42, and Aβ43 imaged after 12 hours of incubation at 25°C are shown in panels A, B, and C, respectively. Images from 37°C incubated stocks are shown in panels D, E, and F, respectively. Scale bars correspond to 200 nm. Fibrillar structures associated with clustered aggregates are indicated by arrows. ThT fluorescence intensities observed over 12 hours of incubation at 25°C are shown in panel G. Values represent average values of ThT fluorescence intensity ± standard deviation. BL denotes basal fluorescence of ThT in absence of peptides.