Absence of systemic immune and inflammatory changes in CD11c-MyD88 KO DIO mice.

<p>(A-C) Total splenocyte count, percent splenic macrophages (Mφ), DCs, T cells, B cells, and Tregs in Cre- and Cre+ DIO mice. n = 5 mice per group (ns, no significant difference <i>vs</i>. Cre- group). (D-E) qRT-PCR analysis of <i>Tnfa</i>, <i>Il6</i>, <i>Mcp1</i>, <i>Il10</i>, <i>and Tgfb</i> mRNA in the spleens and livers of Cre- and Cre+ DIO mice. n = 3 mice per group (ns, no significant difference <i>vs</i>. Cre- group). (F) ELISA-based measurement of TNF, IL-6, MCP-1, IL-1β, and IL-10 in serum of Cre- and Cre+ DIO mice. n = 5 mice per group (ns, no significant difference <i>vs</i>. Cre- group).