Analysis of microvascular density (MVD) and proliferation in TSP-1^-/- and WT tumors.

<p>Blood vessels were blindly evaluated in each tumor section stained with MECA and CD31 antibodies in TSP-1^-/- (A) and WT colons (B). Tumors lacking TSP-1 showed significantly higher MVD as compared to the MVD in the WT tumors (p = 0.0159), (C). IHC for PCNA was performed and positive nuclei were counted in the tumor sections of TSP-1 deficient mice (D) and WT mice (E). PCNA rates were significantly higher in tumors of TSP-1^-/- mice compared to WT tumors (p<.0001), (F).