Additional file 12: of HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer
- Andrew Teschendorff (95936)
- Shih-Han Lee (184672)
- Allison Jones (184670)
- Heidi Fiegl (152035)
- Marie Kalwa (3563498)
- Wolfgang Wagner (47115)
- Kantaraja Chindera (802998)
- Iona Evans (3429239)
- Louis Dubeau (193226)
- Arturo Orjalo (3563501)
- Hugo Horlings (40754)
- Lukas Niederreiter (3563504)
- Arthur Kaser (280904)
- Winnie Yang (453615)
- Ellen Goode (3445394)
- Brooke Fridley (3528998)
- Richard Jenner (3563495)
- Els Berns (3525377)
- Elisabeth Wik (106776)
- Helga Salvesen (106800)
- G. Wisman (3563516)
- Ate van der Zee (3563513)
- Ben Davidson (49188)
- Claes Trope (3563507)
- Sandrina Lambrechts (205147)
- Ignace Vergote (205151)
- Hilary Calvert (3563510)
- Ian Jacobs (1986847)
- Martin Widschwendter (184711)
Publication date
October 2015
DOIAbstract
Enrichment odds ratios (OR) with 95Â % confidence intervals for PCGTs according to different definitions among CpGs undergoing significant hyper- and hypomethylation with HOTAIR (HA) expression (top 500 CpGs) in ovarian cancer samples (INNSBRUCK set). PCGTs are defined as genes associated with SUZ12, EZH2 and H3K27me3 (TriplePCGT) or any one of these factors (SinglePCGT) in human embryonic stem cells (Lee et al. [16]) or as the ~850 genes that gain H3K27me3 upon overexpression of HOTAIR in MDAMB321 breast cancer cells as described by Gupta et al. [10] (PRC2-MDAMB231) or PRC2 targets in human embryonic fibroblast (PRC2-hEF) (Bracken et al. 2006). (PDF 5 kb
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