Additional file 16: of HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer
- Andrew Teschendorff (95936)
- Shih-Han Lee (184672)
- Allison Jones (184670)
- Heidi Fiegl (152035)
- Marie Kalwa (3563498)
- Wolfgang Wagner (47115)
- Kantaraja Chindera (802998)
- Iona Evans (3429239)
- Louis Dubeau (193226)
- Arturo Orjalo (3563501)
- Hugo Horlings (40754)
- Lukas Niederreiter (3563504)
- Arthur Kaser (280904)
- Winnie Yang (453615)
- Ellen Goode (3445394)
- Brooke Fridley (3528998)
- Richard Jenner (3563495)
- Els Berns (3525377)
- Elisabeth Wik (106776)
- Helga Salvesen (106800)
- G. Wisman (3563516)
- Ate van der Zee (3563513)
- Ben Davidson (49188)
- Claes Trope (3563507)
- Sandrina Lambrechts (205147)
- Ignace Vergote (205151)
- Hilary Calvert (3563510)
- Ian Jacobs (1986847)
- Martin Widschwendter (184711)
Publication date
October 2015
DOIAbstract
Predicting HOTAIR expression with the 67-CpG DNA methylation signature. A ROC analysis was used to optimize the cutoff of the correlation score between the 67-CpG DNAme signature and the corresponding DNAme of each of the 63 ovarian cancer samples (INNSBRCUK set, carboplatin-treated subgroup). A correlation score of â0.16 ensures approximately 80Â % sensitivity and 80Â % specificity between the 67-CpG DNAme signature and HOTAIR RNA expression. (PDF 4 kb
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