Macrophage depletion did not improve renal function in Col4a3KO mice.

<p>(<b>A-D</b>) CL treatment did not delay or slow down renal failure measured by serum BUN and urinary ACR, NGAL, and KIM-1. (<b>A, B</b>) Similar increase in BUN and urinary ACR was detected at all time points in KO+CL compared to KO+PBSL or KO mice. (<b>C, D</b>) KO+CL mice showed similar increase in urinary NGAL and KIM-1 as KO+PBSL or KO mice at the age of 8 weeks. Mixed model data analysis (<b>A, B</b>) and Welch corrected ANOVA followed by posthoc pairwise t-test with a Bonferroni correction (<b>C, D</b>) was used to evaluate differences between groups. (<b>A, B</b>) n = 5 to 9 mice per group. (<b>C, D</b>) n = 5 mice per group. CL: clodronate liposomes; PBSL: PBS liposomes.