Predicted coevolving residue pairs within V3.

<p>TP predicted coevolving pairs are connected with a green dash and the FP ones are shown as red bonds. Amino acid numbering is according the HXB2 reference sequence and the V3 coordinate structure solved by Huang et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0143245#pone.0143245.ref011" target="_blank">11</a>] is applied for visualisation. (A) Travers and co-authors [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0143245#pone.0143245.ref042" target="_blank">42</a>] identified 24 coevolving pairs of which the majority is FP. (B) Coevolution predictions made by GREMLIN identified almost exclusively TP.