G10 Elicits IRF3 phosphorylation and Anti-Alphaviral Activity in Cells Lacking IPS1.
- Tina M. Sali (834943)
- Kara M. Pryke (834944)
- Jinu Abraham (834945)
- Andrew Liu (834946)
- Iris Archer (834947)
- Rebecca Broeckel (834948)
- Julia A. Staverosky (834949)
- Jessica L. Smith (834950)
- Ahmed Al-Shammari (834951)
- Lisi Amsler (834952)
- Kayla Sheridan (834953)
- Aaron Nilsen (834954)
- Daniel N. Streblow (190071)
- Victor R. DeFilippis (437634)
Publication date
December 2015
DOIAbstract
<p>(A) Immunoblot of lysates from THF-ISRE-ΔIPS1 following 6h exposure to DMSO, UV-CMV, SeV or 100uM G10 as indicated showing phosphorylation status of IRF3 S386, total IRF3, IPS1, STING, and GAPDH. (B) Average media titers +SD of CHIKV, VEEV, and SINV at 24h (VEEV) or 48h (CHIKV, SINV) post infection obtained from THF-ISRE-ΔIPS1 cells treated with 1% DMSO, 100μM G10, or 1000U/mL IFNβ as indicated. Infections were performed in triplicate.</p
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