Abrogation of G10-Mediated Antiviral Activity and ISG Expression in Cells Lacking STAT1.
- Tina M. Sali (834943)
- Kara M. Pryke (834944)
- Jinu Abraham (834945)
- Andrew Liu (834946)
- Iris Archer (834947)
- Rebecca Broeckel (834948)
- Julia A. Staverosky (834949)
- Jessica L. Smith (834950)
- Ahmed Al-Shammari (834951)
- Lisi Amsler (834952)
- Kayla Sheridan (834953)
- Aaron Nilsen (834954)
- Daniel N. Streblow (190071)
- Victor R. DeFilippis (437634)
Publication date
December 2015
DOIAbstract
<p>(A) Average media titers ±SD of CHIKV, VEEV, and SINV at 24h (VEEV) or 48h (CHIKV, SINV) obtained from THF-ISRE-ΔSTAT1 cells treated with 1% DMSO, 100μM G10, or 1000U/mL IFNβ as indicated. Infections were performed in triplicate. (B) Synthesis of Mx2 and ISG56 proteins in THF-ISRE and THF-ISRE-ΔSTAT1 following 24h exposure to SeV, UV-CMV, 1000U/mL IFNβ or 100μM G10 as indicated.</p
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