AIC649 induces similar cytokine release kinetics in mice and woodchucks.

<p>Three healthy BALB/c mice / time point were treated once with 1 x 10⁵ U AIC649 i.p. (A) or 2.5 x 10⁴ U AIC649 i.m. (B). Mice were sacrificed at the indicated time points and plasma samples were pooled. The pooled plasma samples were subjected to duplicate cytokine determination. Plasma samples from non-injected mice were used as controls. Given are the means +/- SD. (C): Three healthy woodchucks were treated once with 3.9 x 10⁶ U AIC649 /ml or vehicle. Blood was drawn at the indicated time points and subjected to determination of cytokine transcript levels. Results are given as mean fold change relative to pre-treatment (t = 0) levels +/- SD.