<p>A: Cells were treated with 200 nM epoxomicin for 1 hour. B: Cells were treated with 500 nM bortezomib for 1 hour. The relative levels of all peptides identified by MS/MS analysis in each of the inhibitor-treated replicates was compared to the average level of the peptide in the untreated control replicates. The <i>y</i>-axis represents the relative peptide levels (log-scale) and the <i>x</i>-axis represents the rank order of peptides sorted according to the relative level. If the ratio was <0.20 or >5.0, the value was capped at 0.20 or 5.0 to reflect the typical signal to noise ratio. Red circles indicate the ratio of each replicate of identified peptides in inhibitor-treated cells, expressed relative to the average control value. Black ...
The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of...
<p>A) U87MG cells were seeded in a 96-well plate at a density of 10,000 cells per well. Cells were p...
<p>A,B: HEK293T cells were treated for 1 hour with the indicated concentration of bortezomib. Peptid...
<p>The level of peptide in each biological replicate, relative to the average control level, was det...
<p>Panels A–F represent data from experiments on SH-SY5Y cells treated with (A) 2.5 µM MG132 for 35 ...
<p>The relative levels of all peptides identified by MS/MS analysis in the Q7Q111 (A) and Q111Q111 (...
<p>Wild type yeast (top panel) or yeast deleted for drug transporter genes <i>PDR5</i> (second panel...
<div><p>Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 sub...
<p>Panels A–C represent data from experiments on HEK293T cells treated with (A) 100 µM bestatin meth...
<p>(A) Proteasome inhibitors MG132 and EPOX reduced the numbers of LANA-positive cells. HUVEC grown ...
<p>Three experiments were considered for this analysis: HEK293T cells treated for 1 hour with 50 or ...
<div><p>The proteasome cleaves intracellular proteins into peptides. Earlier studies found that trea...
<p>In this experiment, the two replicates of Q7Q7 cells were labeled with D0- and D3-TMAB-NHS, one r...
Peptides derived from cytosolic, mitochondrial, and nuclear proteins have been detected in extracts ...
<p>Peptides observed in multiple experiments were chosen for this analysis. Different peptides are p...
The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of...
<p>A) U87MG cells were seeded in a 96-well plate at a density of 10,000 cells per well. Cells were p...
<p>A,B: HEK293T cells were treated for 1 hour with the indicated concentration of bortezomib. Peptid...
<p>The level of peptide in each biological replicate, relative to the average control level, was det...
<p>Panels A–F represent data from experiments on SH-SY5Y cells treated with (A) 2.5 µM MG132 for 35 ...
<p>The relative levels of all peptides identified by MS/MS analysis in the Q7Q111 (A) and Q111Q111 (...
<p>Wild type yeast (top panel) or yeast deleted for drug transporter genes <i>PDR5</i> (second panel...
<div><p>Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 sub...
<p>Panels A–C represent data from experiments on HEK293T cells treated with (A) 100 µM bestatin meth...
<p>(A) Proteasome inhibitors MG132 and EPOX reduced the numbers of LANA-positive cells. HUVEC grown ...
<p>Three experiments were considered for this analysis: HEK293T cells treated for 1 hour with 50 or ...
<div><p>The proteasome cleaves intracellular proteins into peptides. Earlier studies found that trea...
<p>In this experiment, the two replicates of Q7Q7 cells were labeled with D0- and D3-TMAB-NHS, one r...
Peptides derived from cytosolic, mitochondrial, and nuclear proteins have been detected in extracts ...
<p>Peptides observed in multiple experiments were chosen for this analysis. Different peptides are p...
The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of...
<p>A) U87MG cells were seeded in a 96-well plate at a density of 10,000 cells per well. Cells were p...
<p>A,B: HEK293T cells were treated for 1 hour with the indicated concentration of bortezomib. Peptid...