Iba-1 (red) staining of cortical (A) and hippocampal (C) areas of brains devoid of plaques from WT and APP-Tg mice fed with SD or HFD for 2 months. Iba-1+cells were counted from different fields of the cortex (n = 20 from two animals) and hippocampus (n = 10 from two animals). ** and *** indicate p < 0.01 and p < 0.001, respectively. (two-way ANOVA with Bonferroni post-test)
Lack of amyloid plaque deposition at 3 months. (A) Thioflavin-S staining confirms absence of amyloid...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Synaptophysin and MAP2 immunostaining in the hippocampus. (a)Enlarged view of synaptophysin staining...
Positive pixel count of oil O-red staining in the liver of WT and APP-Tg mice fed with SD or HFD for...
Brain sections from SD and HFD-fed WT mice at 2 months stained with Thioflavin S (Green). Sections w...
Representative images of hippocampal sections from WT mice fed with SD or HFD for 1 year and stained...
Zoomed-in images of Iba-1 (red) staining of respective time points from Figure 2d. Nucleus was count...
Figure S2. HFD increases Aβ levels in the hippocampi of A7-Tg mice. Soluble Aβ levels in the hippoca...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and ac...
APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...
Figure S6. HFD feeding on IRS-2-deficient A7-Tg mice exacerbates diabetic phenotype. a Effect of HFD...
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease afflicting about on...
Figure S5. Deletion of IRS-2 induces metabolic impairments without significant induction of inflamma...
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Lack of amyloid plaque deposition at 3 months. (A) Thioflavin-S staining confirms absence of amyloid...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Synaptophysin and MAP2 immunostaining in the hippocampus. (a)Enlarged view of synaptophysin staining...
Positive pixel count of oil O-red staining in the liver of WT and APP-Tg mice fed with SD or HFD for...
Brain sections from SD and HFD-fed WT mice at 2 months stained with Thioflavin S (Green). Sections w...
Representative images of hippocampal sections from WT mice fed with SD or HFD for 1 year and stained...
Zoomed-in images of Iba-1 (red) staining of respective time points from Figure 2d. Nucleus was count...
Figure S2. HFD increases Aβ levels in the hippocampi of A7-Tg mice. Soluble Aβ levels in the hippoca...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and ac...
APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...
Figure S6. HFD feeding on IRS-2-deficient A7-Tg mice exacerbates diabetic phenotype. a Effect of HFD...
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease afflicting about on...
Figure S5. Deletion of IRS-2 induces metabolic impairments without significant induction of inflamma...
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Lack of amyloid plaque deposition at 3 months. (A) Thioflavin-S staining confirms absence of amyloid...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Synaptophysin and MAP2 immunostaining in the hippocampus. (a)Enlarged view of synaptophysin staining...