Additional file 3: Figure S2. of Non-alcoholic fatty liver disease induces signs of Alzheimerâs disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Additional file 1: Figure S1. of Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Mickael Audrain (3450377)
Romain Fol (3450359)
Patrick Dutar (3450383)
Brigitte Potier (188065)
Jean-Marie Billard (188060)
Julien Flament (3450380)
Sandro Alves (376415)
Marie-Anne Burlot (3450365)
Gaelle Dufayet-Chaffaud (3450371)
Alexis-Pierre Bemelmans (66149)
Julien Valette (3450362)
Philippe Hantraye (46540)
Nicole Déglon (46541)
Nathalie Cartier (3450368)
Jérome Braudeau (3450374)

January 2016

APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...

Additional file 2: of Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

Gaëlle Dominguez (5055797)
Marie-Lise Maddelein (2019868)
Mélanie Pucelle (5055800)
Yvan Nicaise (5055803)
Claude-Alain Maurage (3446774)
Charles Duyckaerts (261043)
Olivier Cuvillier (256709)
Marie-Bernadette Delisle (392301)

April 2018

Visualization of amyloid deposits was carried out using a DAPI staining. Our preliminary studies sho...

Additional file 2: Figure S2. of Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Mickael Audrain (3450377)
Romain Fol (3450359)
Patrick Dutar (3450383)
Brigitte Potier (188065)
Jean-Marie Billard (188060)
Julien Flament (3450380)
Sandro Alves (376415)
Marie-Anne Burlot (3450365)
Gaelle Dufayet-Chaffaud (3450371)
Alexis-Pierre Bemelmans (66149)
Julien Valette (3450362)
Philippe Hantraye (46540)
Nicole Déglon (46541)
Nathalie Cartier (3450368)
Jérome Braudeau (3450374)

January 2016

AAV-PS1 and AAV-APP mice do not exhibit neuronal defects in terms of PSD-95, GLT-1 and tonic glutama...

Additional file 2: Figure S1. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Brain sections from SD and HFD-fed WT mice at 2 months stained with Thioflavin S (Green). Sections w...

Additional file 4: Figure S3. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Iba-1 (red) staining of cortical (A) and hippocampal (C) areas of brains devoid of plaques from WT a...

Additional file 6: Figure S5. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Representative images of hippocampal sections from WT mice fed with SD or HFD for 1 year and stained...

Additional file 5: Figure S4. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Positive pixel count of oil O-red staining in the liver of WT and APP-Tg mice fed with SD or HFD for...

Additional file 2: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S2. HFD increases Aβ levels in the hippocampi of A7-Tg mice. Soluble Aβ levels in the hippoca...

Additional file 3: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...

RESEARCH Open Access

Do-geun Kim
Antje Krenz
Leon E. Toussaint
Kirk J. Maurer
Sudie-ann Robinson
Angela Yan
Luisa Torres
Margaret S. Bynoe

August 2016

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and ac...

Additional file 2: Figure S2. of Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

Claudia Späni (3487181)
Tobias Suter (3487187)
Rebecca Derungs (3487172)
Maria Ferretti (3487178)
Tobias Welt (3487175)
Fabian Wirth (3487184)
Christoph Gericke (3487193)
Roger Nitsch (3487190)
Luka Kulic (225695)

November 2015

Lack of amyloid plaque deposition at 3 months. (A) Thioflavin-S staining confirms absence of amyloid...

Additional file 6: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S6. HFD feeding on IRS-2-deficient A7-Tg mice exacerbates diabetic phenotype. a Effect of HFD...

Additional file 5: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S5. Deletion of IRS-2 induces metabolic impairments without significant induction of inflamma...

Additional file 4: Figure S2. of Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model

Yi-Ling Liu (278564)
Wei-Ting Chen (167673)
Yu-Yi Lin (3948518)
Po-Hung Lu (3948521)
Shie-Liang Hsieh (170099)
Irene Cheng (3355523)

April 2017

Synaptophysin and MAP2 immunostaining in the hippocampus. (a)Enlarged view of synaptophysin staining...

Additional file 3: Figure S3. of MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease

Maximilian Pohland (4392025)
Maren Pellowska (4848289)
Heike Asseburg (4848298)
Stephanie Hagl (3482792)
Martina Reutzel (4848292)
Aljoscha Joppe (4848295)
Dirk Berressem (1987069)
Schamim Eckert (4848286)
Mario Wurglics (1373676)
Manfred Schubert‐Zsilavecz (4848283)
Gunter Eckert (3482789)

February 2018

Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...

Additional file 1: Figure S1. of Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Mickael Audrain (3450377)
Romain Fol (3450359)
Patrick Dutar (3450383)
Brigitte Potier (188065)
Jean-Marie Billard (188060)
Julien Flament (3450380)
Sandro Alves (376415)
Marie-Anne Burlot (3450365)
Gaelle Dufayet-Chaffaud (3450371)
Alexis-Pierre Bemelmans (66149)
Julien Valette (3450362)
Philippe Hantraye (46540)
Nicole Déglon (46541)
Nathalie Cartier (3450368)
Jérome Braudeau (3450374)

January 2016

APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...

Additional file 2: of Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

Gaëlle Dominguez (5055797)
Marie-Lise Maddelein (2019868)
Mélanie Pucelle (5055800)
Yvan Nicaise (5055803)
Claude-Alain Maurage (3446774)
Charles Duyckaerts (261043)
Olivier Cuvillier (256709)
Marie-Bernadette Delisle (392301)

April 2018

Visualization of amyloid deposits was carried out using a DAPI staining. Our preliminary studies sho...

Additional file 2: Figure S2. of Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Mickael Audrain (3450377)
Romain Fol (3450359)
Patrick Dutar (3450383)
Brigitte Potier (188065)
Jean-Marie Billard (188060)
Julien Flament (3450380)
Sandro Alves (376415)
Marie-Anne Burlot (3450365)
Gaelle Dufayet-Chaffaud (3450371)
Alexis-Pierre Bemelmans (66149)
Julien Valette (3450362)
Philippe Hantraye (46540)
Nicole Déglon (46541)
Nathalie Cartier (3450368)
Jérome Braudeau (3450374)

January 2016

AAV-PS1 and AAV-APP mice do not exhibit neuronal defects in terms of PSD-95, GLT-1 and tonic glutama...

Additional file 2: Figure S1. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Brain sections from SD and HFD-fed WT mice at 2 months stained with Thioflavin S (Green). Sections w...

Additional file 4: Figure S3. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Iba-1 (red) staining of cortical (A) and hippocampal (C) areas of brains devoid of plaques from WT a...

Additional file 6: Figure S5. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Representative images of hippocampal sections from WT mice fed with SD or HFD for 1 year and stained...

Additional file 5: Figure S4. of Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim (3475022)
Antje Krenz (3475025)
Leon Toussaint (3475004)
Kirk Maurer (3475019)
Sudie-Ann Robinson (3475007)
Angela Yan (3475010)
Luisa Torres (3475016)
Margaret Bynoe (3475013)

January 2016

Positive pixel count of oil O-red staining in the liver of WT and APP-Tg mice fed with SD or HFD for...

Additional file 2: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S2. HFD increases Aβ levels in the hippocampi of A7-Tg mice. Soluble Aβ levels in the hippoca...

Additional file 3: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...

RESEARCH Open Access

Do-geun Kim
Antje Krenz
Leon E. Toussaint
Kirk J. Maurer
Sudie-ann Robinson
Angela Yan
Luisa Torres
Margaret S. Bynoe

August 2016

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and ac...

Additional file 2: Figure S2. of Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

Claudia Späni (3487181)
Tobias Suter (3487187)
Rebecca Derungs (3487172)
Maria Ferretti (3487178)
Tobias Welt (3487175)
Fabian Wirth (3487184)
Christoph Gericke (3487193)
Roger Nitsch (3487190)
Luka Kulic (225695)

November 2015

Lack of amyloid plaque deposition at 3 months. (A) Thioflavin-S staining confirms absence of amyloid...

Additional file 6: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S6. HFD feeding on IRS-2-deficient A7-Tg mice exacerbates diabetic phenotype. a Effect of HFD...

Additional file 5: of Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Tomoko Wakabayashi (6582182)
Kazuki Yamaguchi (2879087)
Kentaro Matsui (801399)
Toshiharu Sano (6582185)
Tetsuya Kubota (3613955)
Tadafumi Hashimoto (356570)
Ayako Mano (6582188)
Kaoru Yamada (2282920)
Yuko Matsuo (5618513)
Naoto Kubota (427124)
Takashi Kadowaki (35402)
Takeshi Iwatsubo (197608)

April 2019

Figure S5. Deletion of IRS-2 induces metabolic impairments without significant induction of inflamma...

Additional file 4: Figure S2. of Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model

Yi-Ling Liu (278564)
Wei-Ting Chen (167673)
Yu-Yi Lin (3948518)
Po-Hung Lu (3948521)
Shie-Liang Hsieh (170099)
Irene Cheng (3355523)

April 2017

Synaptophysin and MAP2 immunostaining in the hippocampus. (a)Enlarged view of synaptophysin staining...

Additional file 3: Figure S3. of MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease

Maximilian Pohland (4392025)
Maren Pellowska (4848289)
Heike Asseburg (4848298)
Stephanie Hagl (3482792)
Martina Reutzel (4848292)
Aljoscha Joppe (4848295)
Dirk Berressem (1987069)
Schamim Eckert (4848286)
Mario Wurglics (1373676)
Manfred Schubert‐Zsilavecz (4848283)
Gunter Eckert (3482789)

February 2018

Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...

Additional file 1: Figure S1. of Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Mickael Audrain (3450377)
Romain Fol (3450359)
Patrick Dutar (3450383)
Brigitte Potier (188065)
Jean-Marie Billard (188060)
Julien Flament (3450380)
Sandro Alves (376415)
Marie-Anne Burlot (3450365)
Gaelle Dufayet-Chaffaud (3450371)
Alexis-Pierre Bemelmans (66149)
Julien Valette (3450362)
Philippe Hantraye (46540)
Nicole Déglon (46541)
Nathalie Cartier (3450368)
Jérome Braudeau (3450374)

January 2016

APP is processed in sporadic AD cases. Human samples were obtained from late-onset AD cases (Braak 6...

Additional file 2: of Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

Gaëlle Dominguez (5055797)
Marie-Lise Maddelein (2019868)
Mélanie Pucelle (5055800)
Yvan Nicaise (5055803)
Claude-Alain Maurage (3446774)
Charles Duyckaerts (261043)
Olivier Cuvillier (256709)
Marie-Bernadette Delisle (392301)

April 2018

Visualization of amyloid deposits was carried out using a DAPI staining. Our preliminary studies sho...

Additional file 2: Figure S2. of Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Mickael Audrain (3450377)
Romain Fol (3450359)
Patrick Dutar (3450383)
Brigitte Potier (188065)
Jean-Marie Billard (188060)
Julien Flament (3450380)
Sandro Alves (376415)
Marie-Anne Burlot (3450365)
Gaelle Dufayet-Chaffaud (3450371)
Alexis-Pierre Bemelmans (66149)
Julien Valette (3450362)
Philippe Hantraye (46540)
Nicole Déglon (46541)
Nathalie Cartier (3450368)
Jérome Braudeau (3450374)

January 2016

AAV-PS1 and AAV-APP mice do not exhibit neuronal defects in terms of PSD-95, GLT-1 and tonic glutama...

Additional file 3: Figure S2. of Non-alcoholic fatty liver disease induces signs of Alzheimerâs disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Abstract

Extracted data

Additional file 3: Figure S2. of Non-alcoholic fatty liver disease induces signs of Alzheimerâs disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Abstract

Extracted data

Related items

Related items

Additional file 3: Figure S2. of Non-alcoholic fatty liver disease induces signs of Alzheimerâs disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Abstract

Extracted data

Additional file 3: Figure S2. of Non-alcoholic fatty liver disease induces signs of Alzheimerâs disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Abstract

Extracted data

Related items

Related items

Additional file 3: Figure S2. of Non-alcoholic fatty liver disease induces signs of Alzheimerâs disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Additional file 3: Figure S2. of Non-alcoholic fatty liver disease induces signs of Alzheimerâs disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model