Samples of transmission electron microscopy images of thoracic ganglia and antennal lobes in <i>Drosophila</i> LRRK2 mutant (A) and after treatment with 1% in L<sup>-</sup>/A<sup>+</sup> insects (B, C) and 10% L<sup>+</sup>/A<sup>+</sup> (D-F) extract of <i>Wse</i>.
- Francescaelena De Rose (648740)
- Roberto Marotta (445587)
- Simone Poddighe (451721)
- Giuseppe Talani (535463)
- Tiziano Catelani (540651)
- Maria Dolores Setzu (451723)
- Paolo Solla (451724)
- Francesco Marrosu (304911)
- Enrico Sanna (535472)
- Sanjay Kasture (648744)
- Elio Acquas (648745)
- Anna Liscia (451727)
Publication date
January 2016
DOIAbstract
<p>(A) abnormal mitochondria in the thoracic ganglia neuropil of <i>Drosophila</i> LRRK2. (B, C) conventional mitochondria in thoracic ganglia of <i>Drosophila</i> LRRK2 after treatment with 1% <i>Wse</i> L<sup>-</sup>/A<sup>+</sup>imaged at low (B) and higher magnification (C). (D, E) abnormal mitochondria in <i>Drosophila</i> LRRK2 thoracic ganglia cell bodies after treatment with 10% <i>Wse</i>L<sup>+</sup>/A<sup>+</sup>. Note the irregular electron-dense substance clearly recognizable inside the mitochondria. (F and Inset) numerous endosomes are present inside the antennal lobes neurites of <i>Drosophila</i> LRRK2 after treatment with 10% <i>Wse</i>. Scale bars are 0.5 μm except in B that is 2.5 μm.</p
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