siRNA screening in vitro analysis for 81 COPD candidate genes. For the 81 candidate genes, the detailed gene information, selection method, and annotation are shown in the tab "Gene Selection Methods". The siRNA knockdown results in three trials are shown in the tab "siRNA summary". (XLSX 92.6 kb
Additional file 1: Table S1. PCR primer sequences for NTHi and Mcat genes. Figure S1. NTHi gene RNA ...
Background: Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is l...
Supplemental Figures: Additional figures to support the findings of this study. (PDF 780 kb
Annotated variants for the 81 COPD candidate genes. Whole exome sequencing variants identified in th...
COPD candidate genes prioritized by the VAAST analysis. Results from different VAAST run settings (T...
The abundance of gene expression in primary human epithelial cell cultures using RNA-Seq. Expression...
Supplementary methods. Detailed methods description regarding classification of COPD, sequencing pro...
Gene burden analysis of common variants. The table present the SKAT analysis of gene burden of commo...
Tables S1, S2, S3, S4, S5 and S6. Table S1. This table provides: a) Gene-specific assay information ...
The information of Sanger sequencing validation for seven exonic variants of TACC2
Table S1. List of the genes screened for association to higher Chronic Obstructive Pulmonary Disease...
Probe sets replicated in both replication sets (UBC and Groningen) in the lung eQTL analyses. A tabl...
Pairwise linkage disequilibrium (LD) of associated variants. A list of detected genetic variants fou...
Supplemental Methods. Additional detail regarding the methods in this study. (PDF 56 kb
Supplemental Tables: Additional tables to support the findings of this study. Table S4. Differential...
Additional file 1: Table S1. PCR primer sequences for NTHi and Mcat genes. Figure S1. NTHi gene RNA ...
Background: Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is l...
Supplemental Figures: Additional figures to support the findings of this study. (PDF 780 kb
Annotated variants for the 81 COPD candidate genes. Whole exome sequencing variants identified in th...
COPD candidate genes prioritized by the VAAST analysis. Results from different VAAST run settings (T...
The abundance of gene expression in primary human epithelial cell cultures using RNA-Seq. Expression...
Supplementary methods. Detailed methods description regarding classification of COPD, sequencing pro...
Gene burden analysis of common variants. The table present the SKAT analysis of gene burden of commo...
Tables S1, S2, S3, S4, S5 and S6. Table S1. This table provides: a) Gene-specific assay information ...
The information of Sanger sequencing validation for seven exonic variants of TACC2
Table S1. List of the genes screened for association to higher Chronic Obstructive Pulmonary Disease...
Probe sets replicated in both replication sets (UBC and Groningen) in the lung eQTL analyses. A tabl...
Pairwise linkage disequilibrium (LD) of associated variants. A list of detected genetic variants fou...
Supplemental Methods. Additional detail regarding the methods in this study. (PDF 56 kb
Supplemental Tables: Additional tables to support the findings of this study. Table S4. Differential...
Additional file 1: Table S1. PCR primer sequences for NTHi and Mcat genes. Figure S1. NTHi gene RNA ...
Background: Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is l...
Supplemental Figures: Additional figures to support the findings of this study. (PDF 780 kb