Histopathology of amoebic liver abscesses.

<p>0.4 μm sections of hamster’s livers treated as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0146287#pone.0146287.g010" target="_blank">Fig 10</a>, were processed for hematoxylin-eosin staining and observed under light microscope. <b>A)</b> Animals not inoculated with trophozoites and orally treated with pathogens-free water. <b>B, C)</b> Hamsters intraportally inoculated with 3 x 10⁶ trophozoites and treated with 50 μl of ethanol each 8 h (2 days before and 10 days after inoculation). <b>B)</b> Granulomatous reaction representative of damage produced. <b>C)</b> Magnification of a granuloma. <b>D, E)</b> Hamsters intraportally inoculated with 3 x 10⁶ trophozoites and treated with 100 mg/Kg of resveratrol (diluted in 50 μL of ethanol) each 8 h (2 days before and 10 days after inoculation). <b>D)</b> Liver without damage after resveratrol-treatment of animals. <b>E)</b> Liver with small abscesses. Square: magnified area showing a trophozoite. Arrows: granulomas. <b>F)</b> Animals intraportally inoculated with 3 x 10⁶ trophozoites and treated with 20 mg/Kg of metronidazole each 8 h (2 days before and 10 days after inoculation). LP: liver parenchyma. CV: centrolobulillar vein. H: hepatocytes. N: necrosis area. IR: inflammatory reaction. PV: a branch of the portal vein. Arrowheads: trophozoites. Arrows: epithelioid cells.