SC are highly tumorigenic but do not show differences in tumor incidence compared to adherent differentiated counterparts.

<p>(<i>a</i>) Primary SC induce tumors in mice. (<i>b</i>) Tumor weight of the generated tumor xenografts from primary SC. (<i>c</i>) Xenograft derived from primary SC recapitulate the phenotype of the primary tumor after serial transplantation in mice. Magnification 10x. (<i>d</i>) Tumor growth in mice after injection of SC and their differentiated counterpart. Tumor incidence is indicated within the graph. Data are presented as mean ± SEM, *P<0.05.