MLE mutation affects RNAi efficiency.

<p><b>(A)</b> Wing phenotypes from female flies in which Notch dsRNA expression is induced by <i>C96-GAL4</i>. Class1: wild type; class 2: missing margin bristles and absent notching; class 3: moderate notching; class 4: extensive notching; class 5: missing most of the wing margins; class 6: complete lack of margins and reduced wing blade. The chart on the right side of the figure represents the <i>Notch</i> RNAi wing phenotypes distribution in <i>wild type</i>, <i>mle</i> homozygous mutant and <i>mle</i> heterozygous mutant background. The results are the sum of three to six independent crosses per genotype. <b>(B)</b> Wing phenotypes from female flies in which Egfr dsRNA expression is induced by <i>ms1096-GAL4</i>. Class1: wild type; class 2: all the veins present; class 3: absent anterior cross vein (acv) or presence of a partial longitudinal vein; class 4: absent acv plus one partial longitudinal vein; class 5: absent acv plus two partial longitudinal veins; class 6: acv vein absent plus one longitudinal vein absent plus one partial longitudinal vein; class 7: most of the veins absent. The chart on the right side of the figure represents the <i>Egfr</i> RNAi wing phenotypes distribution respectively in <i>wild type</i> and <i>mle</i> homozygous mutant background. The results are the sum of four to five independent crosses per genotype.