Effects of OXA on fasting serum insulin levels.

<p><i>db/+</i> mice received the vehicle (0.9% NaCl), and <i>db/db</i> mice received the vehicle and OXA (150, 350, 550, 750 mg/kg of body weight) or PIO (100 mg/kg of body weight) respectively for 12 weeks. Then, an 8-h fasting blood sample was collected for the detection of insulin. Results are expressed as the mean ± SD, n = 5. OXA: oxamate; PIO: pioglitazone. **: <i>p</i> < 0.01 as compared to the vehicle <i>db/+</i> mice; ##: <i>p</i> < 0.01 as compared to the vehicle <i>db/db</i> mice (one-way ANOVA followed by Student-Newman-Keuls test).