H&E stains of primary tumor tissue and orthotopic tumor from the GBM variant cell lines showing specific features of each variant.

<p>The JHH-505 primary tumor has features of a GBM such as vascular proliferation and dense cellular areas (A) while certain areas contain round, regular oligodendroglial appearing cells (B). The JHH-505 xenograft tumor also contains histological characteristics consistent with GBM-O, including dense (C) and less cellular (D) regions with oligodendroglial appearing cells. The JHU-0879 primary tumor has areas consistent with PNET with hypercellularity containing cells with scant cytoplasm and prominent nucleoli (E). The JHU-0879 xenograft also has PNET features, such as densely packed cells and prominent nucleoli (F). Arrows highlight mitotic or apoptotic cells. Magnification for panel A is 100X, panel B-F are 400X.