Model of HEXIM-dependent regulation of wing disc development.

<p>(A) In WT wing pouch, HEXIM regulates hedgehog signaling and so its transcriptional effector Ci. (B) In HEXIM knockdown background, Hh is strongly induced and so Ci, and provokes apoptosis, which activates apoptosis-mediated compensatory proliferation. The resulting patterning defects prevent wing development despite the compensatory proliferation.