Scaling of total synaptic input current with network size.

<p>(A) Synaptic input current as a function of the number of columns. Shown are the averaged values over different neuron densities (mean ± SEM) as a function of column number for the inputs into L2/3 pyramidal cells (solid blue), L2/3 interneurons (solid red), L5 pyramidal cells (dotted blue) and L5 interneurons (dotted red). The region of currents which yield <i>in vivo</i>-like behavior (cf. black region in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004930#pcbi.1004930.g006" target="_blank">Fig 6A</a>, <i>D</i>_KS < 0.4) is marked in blue for <i>I</i>_ex and in red for <i>I</i>_inh. (B) Same as in A, but synaptic input as a function of total cell density, averaged over column numbers ≥ 5. The dotted horizontal lines show the upper and lower bound of densities found in anatomical studies.