Change in performance and VO_2max (mL·min^-1) with blood donation and RBC re-infusion in Part A of the Study.

<p>Data is presented as percent change from baseline, with a line connecting means. The graph shows the effects of blood donation and RBC re-infusion on repeated testing for time to exhaustion and VO_2max in the Transfusion group, and changes over time with repeated testing only in the Control group. For effects of blood donation baseline was set to Week 0, and changes in data on VO_2max and time to exhaustion calculated to 48 h and 16 weeks after donation. For effects of RBC re-infusion baseline was set to Week 16. MANOVA demonstrated a difference over time between groups, and differences between groups at each time point (oneway ANOVA, p<0.1) are indicated by brackets. Changes at week seven is not shown, and results from tests weeks 19–21 collated. Control as dashed line (-—-), Transfusion as solid line (—). Difference between groups over time investigated by repeated measures MANOVA was significant (F = 12, p-value by Greenhouse-Geisser ε = 0.03), and one-way ANOVA at each time-point subsequently calculated.