Additional file 5: Figure S2. of Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine

Unsupervised hierarchical clustering of tumor cells by functional dependency. (A) Grouping of drop-out patterns using outlier genes, where rows correspond to genes and columns correspond to cell lines. Non-outlier genes are colored in grey as they represent non-sensitive hits. The right inset provides a zoom-in view of the yellow cluster with the vast majority of hematological lines. The full size heatmap, dendrograms and labels have been included as Additional file 6. (B) Grouping using outlier genes from the Wnt pathway. (DOCX 1164 kb