DCs have increased activation markers in CD11c-<i>Ifnar1</i>^-/- mice.

<p>DCs (CD3-negative, CD19-negative, CD11c-positive, MHCII-positive) from CD11c-<i>Ifnar1</i>^-/- mice and littermate controls (cre-negative) 3 days after innoculation with CW3 were quantified (<b>A</b>) and stained for surface markers (<b>B</b>). The geometric mean fluorescence intensity (Geo. MFI) is shown for MHC molecules MHCI-K^b and MHCII-IA/IE, and markers of activation: CD40, CD80, and CD86. Geometric MFIs were normalized in each experiment to the average geometric MFI of each marker on DCs from naïve mice (uninfected cre-positive and cre-negative littermates). Representative histograms are shown. Data is combined from two experiments and individual mice are represented by each data point. Statistical significance was determined by 1-way ANOVA. n.s = p>0.05, * = p≤0.05, *** = p≤0.001, **** = p≤0.0001.