<p>Variable 180 was identified as propranolol. (Red line) indicates the median <i>m/z</i> intensity. (A) Represent the data for 3 <i>P</i>. <i>putida</i> strains, 4 concentrations of propranolol and 3 time points, dashed lines separate different concentration levels of propranolol and solid line separates different strains. (B) Represent the data for 3 <i>P</i>. <i>putida</i> strains, 3 concentrations of propranolol and 1 time point at 60 min, dashed lines separates different strains.</p
<p>Abbreviations: AUC = area under the concentration-time curve; Cl = clearance; C<sub>max</sub> = p...
Exposure of 1,000 simulated patients are represented as box plots in each lesion to visualize the di...
Human pharmaceuticals have been detected in wastewater treatment plants, rivers, and estuaries throu...
<p>Metabolites were detected and identified by GC-MS. Metabolites indicated in black were observed, ...
<p>Bar graphs represent the average concentration of serum metabolites for all time-points and doses...
<p>Measurements made at start (start), after five weeks (4.5w and 5w), and/or after six weeks (6w) e...
<p>Figure depicts six clusters of metabolite patterns. Logged, mean-scaled and normalized combined Δ...
<p>(a) 2D PCA plot of phenotype profiles for negative control (DMSO) and 12 active compounds at diff...
<p>Important metabolites were selected by volcano plot which is a combination of fold change analysi...
<p>Schematic illustration of relevant reactions from the TCA cycle and glutaminolysis. Absolute intr...
<p>(A) Heat map of 284 metabolites in rat plasma samples clustered by concentration profile. Sample ...
Kaplan-Meier curves depicting survival profiles for rats pre-treated with (A) 1 mL/kg or (B) 3 mL/kg...
<p>Box plots indicate the distribution of magnitudes of peak intensity levels of key metabolic pheno...
<p>Bar graphs represent the average concentration of liver metabolites for all time-points and doses...
<p>The level of peptide in each biological replicate, relative to the average control level, was det...
<p>Abbreviations: AUC = area under the concentration-time curve; Cl = clearance; C<sub>max</sub> = p...
Exposure of 1,000 simulated patients are represented as box plots in each lesion to visualize the di...
Human pharmaceuticals have been detected in wastewater treatment plants, rivers, and estuaries throu...
<p>Metabolites were detected and identified by GC-MS. Metabolites indicated in black were observed, ...
<p>Bar graphs represent the average concentration of serum metabolites for all time-points and doses...
<p>Measurements made at start (start), after five weeks (4.5w and 5w), and/or after six weeks (6w) e...
<p>Figure depicts six clusters of metabolite patterns. Logged, mean-scaled and normalized combined Δ...
<p>(a) 2D PCA plot of phenotype profiles for negative control (DMSO) and 12 active compounds at diff...
<p>Important metabolites were selected by volcano plot which is a combination of fold change analysi...
<p>Schematic illustration of relevant reactions from the TCA cycle and glutaminolysis. Absolute intr...
<p>(A) Heat map of 284 metabolites in rat plasma samples clustered by concentration profile. Sample ...
Kaplan-Meier curves depicting survival profiles for rats pre-treated with (A) 1 mL/kg or (B) 3 mL/kg...
<p>Box plots indicate the distribution of magnitudes of peak intensity levels of key metabolic pheno...
<p>Bar graphs represent the average concentration of liver metabolites for all time-points and doses...
<p>The level of peptide in each biological replicate, relative to the average control level, was det...
<p>Abbreviations: AUC = area under the concentration-time curve; Cl = clearance; C<sub>max</sub> = p...
Exposure of 1,000 simulated patients are represented as box plots in each lesion to visualize the di...
Human pharmaceuticals have been detected in wastewater treatment plants, rivers, and estuaries throu...